Why do long-term Covid-19 patients have neurological problems? – VnExpress

The body’s immune response triggered after contracting Covid-19 can damage brain blood vessels, leading to neurological symptoms.

Patients after Covid-19 often face a series of neurological symptoms including headache, fatigue, loss of taste and smell, insomnia or brain fog. A study published in Brain magazine July 5 by scientists from National Institutes of Health (NIH) analyzed the brain examination results of 9 cases of sudden death after infection with the SARS-CoV-2 virus. The results show that the body’s immune response activated after contracting Covid-19 can damage brain blood vessels.

The researchers did not find the Sars-CoV-2 virus in the patient’s brain, instead, protein antibodies produced by the immune system in response to the virus attacked the cells lining the brain’s blood vessels. cause inflammation and damage.

According to scientist Avindra Nath, the study’s lead author, the team had previously seen vascular lesions and inflammation in the brains of Covid-19 patients after autopsies, but could not explain it. solve the cause. Therefore, the study provides insight into the causes of neurological problems caused by Covid-19 and the body’s immune response mechanisms.

Patients after Covid-19 often face a series of neurological symptoms. Image:Times of India

To explore this immune response, the researchers looked at images of brain blood vessel damage from stroke survivors aged 24 to 73. The results were compared with 10 control groups, then, Scientists examine neuroinflammatory syndromes and immune responses using immunohistochemical techniques.

Scientists have discovered that antibodies created against Covid-19 mistakenly attack cells that form the “blood-brain barrier” – a structure designed to stop the virus from attacking the brain and allowing nutrients to enter the brain. necessary to go through. Damage to these cells can cause protein leakage, bleeding and clotting, which increases the risk of stroke.

The fistula also activates macrophage immune cells that congregate in the brain to repair damage, causing inflammation. At the same time, normal cellular activity in these areas is severely disrupted, affecting their ability to detoxify and regulate metabolism.

Scientist Avindra Nath said the findings provide evidence to explain the cause of neurological symptoms. “It is possible that an immune response persists in patients with persistent Covid-19 syndrome leading to nerve cell damage. A drug that reduces the immune response could help limit neurological symptoms. during the prolonged period of Covid-19,” added Mr. Nath.

Hong Thao (follow The Econimic Times)


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