Health

Who should inject monoclonal antibodies against Covid-19? – VnExpress


People who are immunocompromised, cancer, use immunosuppressive drugs, are allergic to vaccine components… can inject monoclonal antibodies against Covid-19 at Tam Anh Hospital.

On the first day of AstraZeneca’s Covid-19 monoclonal antibody consultation week on VnExpress, the system received hundreds of questions about subjects injected with this antibody: HIV-infected people who are on antiretroviral drugs, cancer patients who are receiving immunosuppressive drugs, lupus erythematosus patients, children with Congenital adrenal hyperplasia, people who have had severe allergies in previous vaccinations… can they be vaccinated? How long is the protection of antibodies? Register how? Cost and procedure of injection?…

“Many people wait for monoclonal antibody therapy when they are unable to receive the Covid-19 vaccine at the time of treatment or are prone to weakened resistance, so they are at risk of severe illness and death if they contract Covid-19,” according to Assoc. . Dr. Tran Quang Binh – Professional Director of Tam Anh General Hospital in Ho Chi Minh City.

Patient examined at Oncology Department, Tam Anh General Hospital. Photo: Thuy Nguyen

Sending a question about the week of consultation, Ms. Vo Nguyen Minh Thuy (43 years old, Yen Bai), shared: “When the locality opened the Covid-19 vaccination round, I was undergoing chemotherapy so I could not inject it. I am currently drug-free. After 2 weeks, can I inject monoclonal antibodies?”

According to Dr. BS Vu Huu Khiem – Head of Oncology Department, Tam Anh General Hospital, Hanoi, when chemicals attack immune cells, the body’s blood cells will weaken the body’s immune system. This process can take up to several months to give the body enough time to recover to normal health. Therefore, in the situation of Covid-19, cancer patients who have just undergone chemotherapy and radiation therapy have a very high risk of contracting Covid-19 and the disease will progress more severely than the general population. Therefore, they should inject monoclonal antibodies to obtain early and long-lasting protection.

Many readers wonder “can monoclonal antibodies replace vaccines?”. Associate Professor Tran Quang Binh emphasized: “Monoclonal antibodies do not replace the Covid-19 vaccine for the community, but are only aimed at people who are immunocompromised or unable to respond adequately to the immune system, or are not able to produce an immune response.” adequate antibodies after the full dose of vaccine has been administered and for those who cannot receive the vaccine due to a serious adverse reaction to the Covid-19 vaccine.”

People with underlying diseases are vaccinated against Covid-19 at Tam Anh General Hospital, but those who do not have enough antibodies after vaccination may need more AstraZeneca monoclonal antibodies.  Photo: Tue Diem

People with underlying diseases are vaccinated against Covid-19 at Tam Anh General Hospital, but those who do not have enough antibodies after vaccination may need more AstraZeneca monoclonal antibodies. Photo: Tue Diem

Prof. TS.BS Ngo Quy Chau, professional director of Tam Anh Hanoi General Hospital, said that monoclonal antibodies against Covid-19 are injected to people aged 12 years and older, weighing 40 kg, at the time of injection was not infected with nCoV and did not have contact with people infected with nCoV; at the same time must fall into one of the cases specified above. People who inject monoclonal antibodies will be screened before injection, injection and post-injection care.

In Vietnam, according to statistics from the Ministry of Health, there are currently nearly 230,000 people infected with HIV, 6,100 organ transplant cases, more than 182,500 new cancer cases… This is a vulnerable group, need more data. protection against Covid-19. With the support and licensing of the Ministry of Health, AstraZeneca Vietnam and Vietnam Vaccine Joint Stock Company (VNVC), Tam Anh General Hospital System in Hanoi and Ho Chi Minh City is expected to deploy monoclonal antibody injection to prevent Covid. -19 at the end of March.

Patients have their temperature and blood pressure measured before entering the clinic for screening for Covid-19 vaccination.  Photo: Thuy Nguyen

Patients have their temperature and blood pressure measured before entering the clinic for screening for Covid-19 vaccination. Photo: Thuy Nguyen

According to the manufacturer’s representative, the prophylactic monoclonal antibody against Covid-19 is injected deeply intramuscularly, a dose of two injections at the same time, can produce antibodies after a few hours of injection, the protective effect is 83%, even with variable infection. strain of Omicron and there were no cases of severe illness or death during the 6-month follow-up. This effect is observed in people who are immunocompromised due to disease, are taking immunosuppressive drugs, or may not be able to produce the same immune response to the Covid-19 vaccine as organ transplant recipients. liver transplant, kidney transplant, heart transplant…), cancer, HIV…

On the afternoon of March 16, the Drug Administration of Vietnam (Ministry of Health) recommended not to use monoclonal antibodies against Covid-19 for F0 being treated, after exposure to nCoV in humans who can be vaccinated.

Xuan Le

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