The syndrome that causes men to have no sperm

People with Klinefelter syndrome (excess of female chromosomes) have hypogonadism, poor spermatogenesis or no spermatogenesis, can not have children naturally.

Doctor Dinh Huu Viet, Head of Surgery – Urology and Andrology, Hanoi Hospital of Andrology and Infertility, said that Klinefelter syndrome is a genetic disorder in males, the patient has a pair of sex chromosomes. count X, instead of having only one X chromosome.

“Men with Klinefelter syndrome have chromosome 47XXY, characterized by hypogonadism, endocrine disorders, testicular atrophy, poor spermatogenesis or no spermatogenesis. With assisted reproduction methods, the patient will not be able to have a natural child,” said Doctor Viet.

Male infertility due to Klinefelter syndrome is quite common, accounting for about 3% and is often classified as difficult cases in assisted reproductive and gynecological interventions. Currently, the only method that gives them a chance of having a baby is Micro TESE surgery to find sperm and use that sperm to do IVF with the wife’s egg.

With this method, the doctor will magnify the testicle, intervene deeply into each layer of testicular tissue, select the seminiferous tubules (where sperm are produced) that are qualified to find each sperm.

A patient has a gynecological examination at the Hanoi Hospital of Andrology and Infertility. Image: ID

Micro TESE is also commonly indicated for most cases of nonobstructive infertility due to causes such as: testicular atrophy due to mumps (more than 90% of sperm can be found), Sertoli syndrome, mid-spermogenesis syndrome, etc. genetic abnormalities (most commonly AZF gene deletion mutations on the Y chromosome), chromosomal abnormalities,…

Klinefelter’s patients are often not affected much to the process of living and growing up, so they are almost always diagnosed late, only when they get married and have children, do they go to the doctor. At this time, only specialized tests can detect chromosomal abnormalities.

The late diagnosis of the disease, when the patient is old, also greatly affects the later treatment process. Couples who have regular sex and have not used contraception for a year or 6 months (for women over 35 years old) and still have not had children should have a reproductive health check-up.

Le Nga


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