Risk of re-infection with Covid-19 after taking anti-viral drug Paxlovid – VnExpress

AmericaMany people after being treated for Covid-19 with the antiviral drug Paxlovid are re-infected but do not know because they do not show symptoms.

Dr. Michael Charness, Boston Veterans Administration Medical Center, USA, and colleagues collaborated with a team at Columbia University to look at cases of reinfection with SARS-CoV-2 after treatment with Paxlovid. They found at least two cases of potentially infecting others with reinfection. In particular, a 67-year-old man infected a 6-month-old baby after half an hour of exposure.

Many people who treated Covid-19 with Paxlovid were found to be reinfected with no symptoms. Image: Healthline

This man has just finished his Covid-19 treatment for 12 days. He took Paxlovid for 5 days and felt better. When he came into contact with the child, the person did not have any symptoms, but about eight hours later, he started getting sick again. The baby tested positive about 3 days later, and both his mother and father were also infected.

“This shows that you can be contagious during your recovery, even before symptoms appear. There are certainly many people who re-infected with Covid-19 who are asymptomatic and infect others,” Charness said. other”.

The other case is a 63-year-old man who infects two family members within 3 days of relapse after using Paxlovid for treatment. Based on this study, the US CDC issued new guidelines last week for people who have recovered from Covid-19, treated with Paxlovid.

Specifically, the US CDC stated that people who test positive again and have symptoms after taking antiviral drugs should be isolated for 5 days. The agency says people can end their quarantine for another five days as long as they clear their fever on their own within 24 hours, don’t need fever-reducing medication, and feel better. The CDC also recommends that people wear a mask for 10 days after their symptoms return.

The findings and guidance come as the use of Paxlovid increases in the US. According to the White House, in the past two months, prescriptions for Paxlovid have increased from about 27,000 per week to 182,000 per week.

In clinical trials, Paxlovid reduced the proportion of people at risk of severe Covid-19 being hospitalized by nearly 90% compared with placebo. Therefore, the CDC said, early treatment with this drug is still recommended, but the researchers advise people to be aware that the drug may not completely kill the virus.

Mr. Charness’s research team collected at least 10 cases of Covid-19 relapse after treatment with Paxlovid. Half of them are families, leading the researchers to conclude such cases are not uncommon.

In this study, Charness said researchers watched a person’s viral load drop during treatment with Paxlovid. “Paxlovid stops the virus from replicating in the user’s body. From there, the virus level goes down but rises again in some people nine to 12 days later,” he said.

However, Mr. Charness’s team did a comparative study and found some differences. When looking at 1,000 cases diagnosed with Covid-19 from December 2021 to March 2022 at the US National Basketball Association, without antiretroviral treatment, the team did not find any cases of relapse. infected with Covid-19. The study has not been published and is still being reviewed by scientists.

Thanh Thu (follow CNN)


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