Patient has Covid 505 days

BrotherScientists on April 22 reported a severely immunocompromised patient, suffering from Covid-19 for nearly a year and a half.

The patient was positive for nCoV in early 2020, treated with the antiviral drug remdesiver, and died in 2021. The researchers did not specify the cause of death, saying that this person had some underlying diseases.

It is not clear whether this is the longest nCoV infection or not, because not everyone is tested regularly, for such a long time. However, this patient is the longest positive case officially recorded, according to Dr. Luke Blagdon Snell, infectious disease specialist at the Guy’s & St. Thomas, of the National Health Service (NHS).

Dr Snell and colleagues are expected to report some persistent cases of Covid-19 at a meeting on infectious diseases in Portugal later this week.

The team’s study looked at the risk of developing mutations in “super-long-lasting” infections. Volunteers are 9 patients with Covid for at least 8 weeks. All were immunocompromised due to organ transplants, HIV infection, cancer or treatment for other diseases.

nCoV (yellow) is cultured in a laboratory at the US National Institutes of Health (NIH), 2020. Photo: NIH

Continuous tests showed that nCoV infection lasted an average of 73 days. Two have been positive for the virus for more than a year. Before that, according to the researchers, the longest positive PCR test case was 335 days.

Five patients survived, two cleared the virus without treatment, one was still sick. At the last follow-up visit earlier this year, this patient tested positive for 412 days.

“In prolonged Covid-19 cases, the virus is cleared from the body but symptoms persist. In people with persistent disease, the virus continues to multiply, the test result is positive,” Mr. Snell said. .

To carry out the study, experts analyze the genetic code of the virus to make sure they are the same strain, and that the patient has not contracted Covid-19 more than once. However, genetic sequencing showed that the viruses had changed over time, making them adaptive. Mutations were present in both later circulating strains. Even so, none of the patients developed the worrisome mutations, and there was no evidence that they passed the disease on to others, Snell said.

Experts hope there will be more treatments available for people with persistent viral infections. While these cases are rare, it’s still a concern for people with weakened immune systems, especially as the government begins to deregulate face masks.

Thuc Linh (According to SCMP)


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