Alcohol lowers testosterone levels and damages testicular tissue, which in turn leads to testicular atrophy.
Testicular atrophy is a condition that occurs when the testicles shrink, becoming smaller than their normal size. This condition can reduce sperm production, lower testosterone levels in the body, impotence and decreased sex drive, which in turn affects fertility in men. Many causes can cause testicular atrophy, in which, drinking a lot of alcohol is one of the common causes leading to this condition.
In the structure of the testicles, there are two types of cells that perform many important functions: Leydig cells and Sertoli cells. Leydig cells produce male sex hormones, mainly testosterone. Meanwhile, Sertoli cells help nourish and support the spermatogenic cells in the process of differentiation into sperm. Some studies show that alcohol has the ability to destroy Leydig cells, thereby inhibiting the ability of testes to synthesize testosterone. According to results from a study conducted on 11 young, healthy male volunteers with normal liver function, their blood testosterone levels tended to drop significantly 5 days after being given 220 grams of alcohol. alcohol (about 3 grams of alcohol per kilogram of body weight) per day and continued to decrease throughout the course of the study.
While testicular atrophy can reduce testosterone levels in a man’s body, the lack of testosterone itself also causes tissue in the penis, scrotum, and testicles to shrink. As a result, the testicles are reduced in size, sometimes shrinking to half their normal size.
In addition, the abuse of alcohol can also damage testicular tissue, one of the causes of testicular atrophy. According to results from an animal study by M. Martinez et al. (2009), alcohol can cause the intercellular spaces in the testicular tissue to become denser, the diameter of the semi-coniferous tubules is reduced. changes and necrosis of seminiferous tubular cells, thereby leading to histological abnormalities.
It can be seen that alcohol causes testicular atrophy and affects fertility in men. Therefore, according to the Centers for Disease Control and Prevention (CDC), men should not drink alcohol or should drink less than 2 units of alcohol per day. One unit of alcohol is equivalent to 355 ml of beer, 148 ml of wine or 44 ml of 80-degree wine.
Phuong Quynh (According to NCBI)