The new approach helps to shrink malignancies without affecting healthy cells, the scientists said.
The study was published in the journal Cancer Discovery of the American Cancer Society in September. Experts at the Sanford Burnham Institute Prebys Medical Discovery showed that blocking the formation of nuclear pores could help shrink masses. Malignant neoplasms.
The method was carried out in mice, only to affect cancer-causing tumors without damaging healthy cells. Scientists believe that this could be a new, better treatment for deadly diseases such as leukemia and colorectal cancer.
According to Professor Maximiliano D’Angelo, Sanford Burnham Prebys Institute’s Aging, Aging and Regeneration Program, the nuclear hole is the “door” through which all matter passes.
“By closing this ‘door’, we can selectively kill cancer cells,” he said.
To test the hypothesis, D’Angelo and his colleagues implanted human tumor cells that were no longer capable of forming nuclear holes into mice. The three different types of tumors are melanoma, leukemia, and colorectal cancer. They found that all mice had a smaller tumor that grew more slowly.
“Our findings provide important evidence that this could be a potential, particularly effective treatment for terminally advanced or metastatic cancer,” the team said.
From the above results, scientists are working on drugs that can block the formation of nuclear pores. The process took place at the Conrad Prebys Genomic Center, Sanford Burnham Prebys Institute.
“In addition to treating people with hard-to-treat cancer, we think it can also prevent resistance, which occurs when tumors have distinct properties, against specific therapies,” said spear. Professor D’Angelo said.
Thuc Linh (Follow SBP)