BrotherScientists discovered that a number of factors in the blood, such as cytokines and RNA molecules, determine the disease status and severity of people with Covid-19.
The study was carried out by scientists at the Hull York School of Medicine and the York University Department of Mathematics. They analyzed blood samples of hospitalized Covid-19 patients and discovered signs that make an F0 prone to severe disease, requiring treatment in the intensive care unit. This finding can lay the foundation to help classify and assess the risk of Covid-19 patients becoming seriously ill, reducing pressure at hospitals during the period when the number of infections spikes.
The study, published in the journal iScience, looked at over 160 F0 cases hospitalized during the first and second outbreaks at York and Scarborough University Hospitals. The scientists measured levels of cytokines and chemokines (proteins in the blood that promote an immune response in patients) as well as small RNAs, also known as microRNAs (components that reflect the state of diseased tissues). They show that three factors cytokines, chemokines and microRNAs associated with patient mortality.
The most important factor is cytokines. Lead investigator Dr Nathalie Signoret from the Hull York School of Medicine at York University, said: “Early in the pandemic, scientists found that the more cytokines were released, the more severe the patient’s condition was. This is called a ‘cytokine storm.’ However, a ‘cytokine storm’ also occurs in hospitalized patients with milder symptoms.”
Based on the new research, she thinks scientists could develop blood tests that could provide important information about treatments to doctors.
“In fact, we can consider this as part of routine clinical blood testing that applies to all hospitals, providing a better tool to triage patients and identify those most likely to progress early. severe development,” said Dr. Signoret.
Since the beginning of the pandemic, scientists have struggled to understand how Covid-19 affects individuals. Even among hospitalized patients, treatment needs vary. Some cases require only oxygen, while others require intubation and aggressive treatment.
“Our findings reinforce the thesis that Covid-19 is a disease that develops in stages. It provides doctors with important information, allowing them to tailor treatment according to the severity of the disease. identify those at high risk for severe disease,” said Dr. Dimitris Lagos, lead author of the study.
Dr David Yates, Intensive Care Consultant and Clinical Research Team Leader at York and Scarborough Hospitals, says the work opens up a whole new field of Covid-19. In it, scientists will learn about separate forms of treatment at different stages of the disease.
Thuc Linh (Follow Medical Express)