Eating a lot of fat can cause brain atrophy and depression

AustraliaScientists have discovered that a high-fat diet can affect the brain, increasing the risk of anxiety disorders, depression, cognitive decline.

The study was carried out by Professor Xin-Fu Zhou, Associate Professor Larisa Bobrovskaya and neuroscientists at the University of South Australia. They determined that a high-fat diet for 30 weeks increased the likelihood of diabetes, cognitive decline, development of anxiety disorders and depression, and worsening of Alzheimer’s disease.

Preclinical studies have also shown that cognitively impaired rats are also prone to excessive weight gain due to poor metabolism, caused by brain changes.

According to Associate Professor Bobrovskaya, the study adds to the evidence linking chronic obesity and diabetes to Alzheimer’s disease.

“Obesity and diabetes depress the central nervous system, exacerbate mental disorders and cognitive decline. We have demonstrated this in a mouse study,” said Associate Professor Bobrovskaya. .

Rats were randomly divided into groups, with a standard diet and a high-fat diet for 30 weeks, starting at 8 weeks of age. Food intake, body mass, and glucose levels are monitored at different time intervals. In addition, the researchers also tested the mice for glucose and insulin tolerance and cognitive dysfunction.

Fatty foods such as bacon and sausages. Image: Medical Express

They found that the mice on the high-fat diet gained a lot of weight, developed insulin resistance and started to behave abnormally compared to those fed the standard diet.

The mice with Alzheimer’s had significant cognitive impairment, and there were pathological changes in the brain when fed a high-fat diet.

“Obes are about 55% more likely to develop depression, with diabetes doubling that risk. Our findings highlight the importance of tackling global obesity.” The combination of obesity, advanced age, and diabetes predisposes to cognitive decline, Alzheimer’s disease and other types of mental health disorders,” said Associate Professor Bobrovskaya.

Thuc Linh (Follow Medical Express)


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