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Azoospermia due to Klinefelter syndrome and AZFc deletion – VnExpress


I have no sperm due to both Klinefelter syndrome and AZFc deletion. If my husband and I do IVF, is the probability of success high? (Minh Hieu, Hai Phong)

Reply:

With the development of current science, especially at the Center for Reproductive Support at Tam Anh General Hospital in Ho Chi Minh City (IVFTA-HCM), the possibility of success if you fall into this situation is there. At IVFTA-HCM, we have met many such cases and had children.

When coming to IVFTA-HCM, in addition to helping you and your wife have children, we also help improve the quality of life. The vast majority of patients with Klinefelter syndrome have hypogonadism, leading to early menopause in women and early menopause. These people have genetic problems, so the sex organs are not fully developed like other normal men, especially the “factory” that produces male sex hormones, mainly testosterone. If detected early, treated early, especially by gynecologists and endocrinologists very early and have treatment plan from before 30 years old like in developed countries, will have more chances to have children. Current science has proven that, for Klinefelter cases, the prognosis of men’s quality of life as well as reproductive quality is completely different from that of patients after 30 years of age, but that is not the case. That means it’s hopeless for 35-40 year olds to come to us. There are still cases like you that we can handle easily. In particular, in these cases, we also help improve the quality of life in the following years until the age of 100. We have very good orthopedic doctors, endocrinologists, 30-40 years of experience. We even proactively remind patients to go for annual check-ups to take care of their reproductive health, because when we are a family, we not only need children, but also parents and children. healthy, create value to raise that child to be a good citizen.

Regarding the loss of AZFc fragment, currently according to statistics of organizations and associations around the world, it is still possible to find sperm in these cases. There are conflicting information, there are documents that show that this mutation can be passed on to the next generation, but there are documents that show no difference. While waiting for some difference, in cases of micro-deletion, the male’s spermatogenesis will decrease over time.

In these cases, we actively recommend that patients store sperm if they have been successfully treated for sperm return, or use micro-TESE microsurgery to find sperm. This is a groundbreaking and humane technique. Once we found the sperm and in a small amount that could be stored, it even grew so strong that we were able to split the samples into smaller samples and the patient could treat it for two to three cycles. next.

About 5-7 years ago, we didn’t have much understanding about these cases, most clinicians often advised patients to ask for sperm. Besides, the limitation of technology prevents us from doing that. Regarding genetic issues, the medical knowledge of male infertility associated with genetics is not much. Fortunately, in the last 2-3 years, technology in Vietnam has developed and we have opened our eyes and shared with patients more openly.

We hope that you and your wife have a suitable treatment and soon have good news.

MSc Le Dang Khoa
Head of Southern Studies Unit, IVFTA HCM

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